Disseminated Hailey-Hailey disease treated with topical tacrolimus and oral erythromycin: Case report and review of the literature.

Treatment of Hailey-Hailey Disease of the vulva: a retrospective case series

Background: Hailey-Hailey disease (familial benign chronic pemphigus) of the vulva is a rare autosomal dominant dermatosis characterized by malformation of desmosomes and bullae, particularly in intertriginous areas. Cases: We reviewed the cases of 5 women followed at a single academic institution over a period of 17 years. Of the 5 patients, 4 carried a diagnosis of Hailey-Hailey at the time o...

Methotrexate for refractory Hailey-Hailey disease.

Editor We would like to report the use of methotrexate to treat a female patient with refractory, long standing Hailey–Hailey disease (HHD). To our knowledge, this is only the second case report of methotrexate being used to treat this disease. A 42-year-old woman presented to us with active skin lesions affecting both axillae, groins and lateral aspect of neck (Fig. 1) that had an ondulant cou...

Topical tacrolimus ointment is an effective therapy for Hailey-Hailey disease.

A 67-year-old man with a 10-year history of flexural blistering eruptions also affecting 3 of his brothers was first evaluated in 1987. The patient presented with vesicles, erosions, and erythema in the intertriginous areas but also as multiple truncal plaques (Figure 1). Biopsy specimens showed intraepidermal clefts of varying sizes both suprabasally and higher in the epidermis, as well as the...

Topical tacrolimus and 50% zinc oxide paste for Hailey-Hailey disease: less is more.

Familial benign chronic pemphigus (Hailey-Hailey Disease): use of topical immunomodulators as a modern treatment option.

Benign chronic familial pemphigus (Hailey-Hailey disease) is a rare autosomal dominant blistering skin disorder characterized by suprabasal cell separation (acantholysis) of the epidermis. The Hailey brothers first described it in 1939. Hailey-Hailey disease usually appears in the third or fourth decade, although it can occur at any age. Heat, sweating and friction often exacerbates the disease...